Effect of Probiotic Microbial Cell Preparation (MCP) on fasting blood glucose body weight waist circumference and faecal short chain fatty acids among overweight Malaysian adults: a pilot randomised controlled trial of 4 weeks

Krishnappa P., . and Shyam S., . and Ramamurthy S., . and Mahadzir MDA, . and Barua A., . Effect of Probiotic Microbial Cell Preparation (MCP) on fasting blood glucose body weight waist circumference and faecal short chain fatty acids among overweight Malaysian adults: a pilot randomised controlled trial of 4 weeks. pp. 329-341. ISSN 1394-035X

Probiotic microbial cell preparation (MCP) supplementation is one of the approaches to modulate alterations in gut microbiota (GM). This double-blind randomised controlled trial investigated the effect of 4 weeks of MCP supplementation on fasting blood glucose levels (FBG) body weight (BW) waist circumference (WC) and faecal short chain fatty acids (SCFA) among 24 healthy and overweight (with BMI 23 kg/m2) Malaysian adults. Methods: Twenty-six subjects were randomised to receive either MCP (n 12) or placebo (n14) twice daily for 4 weeks. The probiotic powder contained a mix of six strains namely Lactobacillus acidophilus Lactobacillus lactis Lactobacillus casei Bifidobacterium longum Bifidobacterium bifidum and Bifidobacterium infantis (3.0 x 1010 cfu). FBG BW WC WHR faecal SCFA physical activity levels and dietary intake were measured and changes were determined using repeated measures ANOVA. Results: Twenty-four subjects successfully completed the 4-week study period. Changes in FBG BW WC and SCFA were not significantly different between the groups. Only subjects in the MCP group significantly reduced their energy intake compared to baseline (1671476 vs 1386447 kcal P0.045). Conclusion: A 4-week supplementation of the MCP mix powder did not have significant effects on the variables studied. However the significant reduction in dietary energy intake in the MCP group suggests the potential of probiotics as an adjuvant to dietary therapy for weight loss.

Full text available from: Official URL: http://www.nutriweb.org.my/mjn/publication/23-3/c....

Abstract

Probiotic microbial cell preparation (MCP) supplementation is one of the approaches to modulate alterations in gut microbiota (GM). This double-blind randomised controlled trial investigated the effect of 4 weeks of MCP supplementation on fasting blood glucose levels (FBG) body weight (BW) waist circumference (WC) and faecal short chain fatty acids (SCFA) among 24 healthy and overweight (with BMI 23 kg/m2) Malaysian adults. Methods: Twenty-six subjects were randomised to receive either MCP (n 12) or placebo (n14) twice daily for 4 weeks. The probiotic powder contained a mix of six strains namely Lactobacillus acidophilus Lactobacillus lactis Lactobacillus casei Bifidobacterium longum Bifidobacterium bifidum and Bifidobacterium infantis (3.0 x 1010 cfu). FBG BW WC WHR faecal SCFA physical activity levels and dietary intake were measured and changes were determined using repeated measures ANOVA. Results: Twenty-four subjects successfully completed the 4-week study period. Changes in FBG BW WC and SCFA were not significantly different between the groups. Only subjects in the MCP group significantly reduced their energy intake compared to baseline (1671476 vs 1386447 kcal P0.045). Conclusion: A 4-week supplementation of the MCP mix powder did not have significant effects on the variables studied. However the significant reduction in dietary energy intake in the MCP group suggests the potential of probiotics as an adjuvant to dietary therapy for weight loss.

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Item Type:	Article
AGROVOC Term:	Probiotics
AGROVOC Term:	Blood glucose
AGROVOC Term:	Body weight
AGROVOC Term:	Anthropometry
AGROVOC Term:	Faeces
AGROVOC Term:	Fatty acids
AGROVOC Term:	Overweight
AGROVOC Term:	Fasting
AGROVOC Term:	Intestinal microorganisms
AGROVOC Term:	Intestines
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8003

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