Mini-review: zoonotic agents from ticks in Malaysia

Bolongon Gilmoore G., . and Lim Fang Shiang, . and Noor Azleen M. K., . and Khoo Jing Jing, . and Khor Chee Sieng, . and Sazaly Abu Bakar, . Mini-review: zoonotic agents from ticks in Malaysia. pp. 67-77. ISSN 0121-8126

Ticks serve as vectors of multiple pathogenic bacteria viruses and piroplasms with medical and veterinary importance worldwide. Close contact with animal hosts infested with ticks may result in transmission of zoonotic pathogens from animal reservoirs to humans. In Malaysia past exposure to tick-borne pathogens such as Anaplasma Ehrlichia Babesia and other rickettsial infections have been reported in both human and animals. Research into the presence and transmission of tick-borne zoonotic pathogens is crucial in safeguarding human health. In our laboratory we aim to study the presence of tick-borne pathogens by using molecular techniques and next-generation sequencing (NGS). The detection of bacteria and viruses are performed in ticks collected from farms indigenous people (Orang Asli) villages and forests such as the national parks in Malaysia. The bacterial communities in these ticks were investigated by 16s rRNA amplicon sequencing on NGS platform. Early findings revealed the presence of diverse community of bacteria including pathogens and endosymbionts. On-going efforts include expanding the microbiome investigations into ticks from other regions in Malaysia as well as to intensify the discovery of tick-borne viruses. This review summarizes the current knowledge of potential tick-borne zoonotic agents in Malaysia as well as the recent findings in the investigation of the bacterial and viral agents of ticks from Malaysia undertaken at the Tropical Infectious Diseases Research and Education Centre (TIDREC).

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Abstract

Ticks serve as vectors of multiple pathogenic bacteria viruses and piroplasms with medical and veterinary importance worldwide. Close contact with animal hosts infested with ticks may result in transmission of zoonotic pathogens from animal reservoirs to humans. In Malaysia past exposure to tick-borne pathogens such as Anaplasma Ehrlichia Babesia and other rickettsial infections have been reported in both human and animals. Research into the presence and transmission of tick-borne zoonotic pathogens is crucial in safeguarding human health. In our laboratory we aim to study the presence of tick-borne pathogens by using molecular techniques and next-generation sequencing (NGS). The detection of bacteria and viruses are performed in ticks collected from farms indigenous people (Orang Asli) villages and forests such as the national parks in Malaysia. The bacterial communities in these ticks were investigated by 16s rRNA amplicon sequencing on NGS platform. Early findings revealed the presence of diverse community of bacteria including pathogens and endosymbionts. On-going efforts include expanding the microbiome investigations into ticks from other regions in Malaysia as well as to intensify the discovery of tick-borne viruses. This review summarizes the current knowledge of potential tick-borne zoonotic agents in Malaysia as well as the recent findings in the investigation of the bacterial and viral agents of ticks from Malaysia undertaken at the Tropical Infectious Diseases Research and Education Centre (TIDREC).

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Item Type:	Article
AGROVOC Term:	Ticks
AGROVOC Term:	Pathogenic bacteria
AGROVOC Term:	Tickborne diseases
AGROVOC Term:	Bacterial diseases
AGROVOC Term:	Disease occurrence
AGROVOC Term:	Infection
AGROVOC Term:	Molecular genetics
AGROVOC Term:	Pathogens
AGROVOC Term:	Zoonoses
AGROVOC Term:	Gene sequence
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:54
URI:	http://webagris.upm.edu.my/id/eprint/8280

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