Citation
Mutalib A. R., . and Suhaidah I., . and Salim N. B., . and Rasedee A., . and Noordin M. M., . Serum biochemical changes in mercury chloride-induced renal damage in rats. pp. 1-4. ISSN 9128-2506
Abstract
Eighty Sprague-Dawley rats weighing between 200 to 230g and aged between eight to ten weeks were divided into two groups of 40 rats each. Group 1 (treated) received intravenous injection of 1mL solution containing mercury chloride at the rate of 0.5 mg/kg body weight in 0.85 NaCI through the tail vein. Group 2 (control) was similarly injected with 1mL of 0.85 NaCI. The respective treatment was repeated every alternate day for 10 days before five rats from each group were sacrificed on day 0 and on every for day-interval thereafter beginning 2 weeks after the first injection. Blood samples were analysed for blood urea nitrogen (BUN) serum creatinine serum total protein and serum albumim. Urine samples were analysed to determine the albumin level. The concentration of blood urea nitrogen and serum creatinine increased significantly (p0.05) compared to controls. Serum creatinine serum and urine albumin concentrations showed biphasic responses with the first response in serum creatinine concentration was observed as early as 14 days after the first injection. The results suggested that the mechanism of renal damage in mercury chloride toxicidy occurred in two phases.
Download File
Full text available from:
Official URL: https://www.mavma.org.my/1998-volume-10-issue-no-1...
|
Abstract
Eighty Sprague-Dawley rats weighing between 200 to 230g and aged between eight to ten weeks were divided into two groups of 40 rats each. Group 1 (treated) received intravenous injection of 1mL solution containing mercury chloride at the rate of 0.5 mg/kg body weight in 0.85 NaCI through the tail vein. Group 2 (control) was similarly injected with 1mL of 0.85 NaCI. The respective treatment was repeated every alternate day for 10 days before five rats from each group were sacrificed on day 0 and on every for day-interval thereafter beginning 2 weeks after the first injection. Blood samples were analysed for blood urea nitrogen (BUN) serum creatinine serum total protein and serum albumim. Urine samples were analysed to determine the albumin level. The concentration of blood urea nitrogen and serum creatinine increased significantly (p0.05) compared to controls. Serum creatinine serum and urine albumin concentrations showed biphasic responses with the first response in serum creatinine concentration was observed as early as 14 days after the first injection. The results suggested that the mechanism of renal damage in mercury chloride toxicidy occurred in two phases.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Rats |
| AGROVOC Term: | Laboratory experimentation |
| AGROVOC Term: | Injection |
| AGROVOC Term: | Mercury |
| AGROVOC Term: | Blood sampling |
| AGROVOC Term: | Urea |
| AGROVOC Term: | Creatinine |
| AGROVOC Term: | Proteins |
| AGROVOC Term: | Albumins |
| AGROVOC Term: | Renal failure |
| Depositing User: | Mr. AFANDI ABDUL MALEK |
| Last Modified: | 24 Apr 2025 00:54 |
| URI: | http://webagris.upm.edu.my/id/eprint/8826 |
Actions (login required)
 |
View Item |
