Citation
Eisheikh H. A., . and Kheir W. M., . and Eltayeb I. B., . and Mousa H. M., . The influence of dieldrin pretreatment on the toxicity of praziquantel in rabbits. pp. 21-24. ISSN 9128-2506
Abstract
Oral administration of dieldrin a known inducer of drug-metabolising enzyme activity at a dose rate of 2.5 mg/kg BW produced no pathological changes in the tissues of treated rabbits and resulted in the induction of the activities of hepatic drug-methabolising enzymes aminopyrine-N-demethylase and aniline 4-hydroxylase. The induction of these enzymes might have protected the rabbits from the lethal effect of praziquantel when given at the dose rate of 2000 mg/kg BW (50 times the therapeutic dose) ten days following dieldrin pretreatment.
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Abstract
Oral administration of dieldrin a known inducer of drug-metabolising enzyme activity at a dose rate of 2.5 mg/kg BW produced no pathological changes in the tissues of treated rabbits and resulted in the induction of the activities of hepatic drug-methabolising enzymes aminopyrine-N-demethylase and aniline 4-hydroxylase. The induction of these enzymes might have protected the rabbits from the lethal effect of praziquantel when given at the dose rate of 2000 mg/kg BW (50 times the therapeutic dose) ten days following dieldrin pretreatment.
Additional Metadata
| Item Type: | Article |
|---|---|
| AGROVOC Term: | Rabbits |
| AGROVOC Term: | Dieldrin |
| AGROVOC Term: | Toxicity |
| AGROVOC Term: | Experimental animals |
| AGROVOC Term: | Experimental design |
| AGROVOC Term: | Microscopy |
| AGROVOC Term: | Data collecting |
| AGROVOC Term: | Sampling |
| AGROVOC Term: | Statistical analysis |
| AGROVOC Term: | Histopathology |
| Depositing User: | Mr. AFANDI ABDUL MALEK |
| Last Modified: | 24 Apr 2025 00:54 |
| URI: | http://webagris.upm.edu.my/id/eprint/9040 |
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