Formulation and stability enhancement using vitamin A encapsulation in ocular abnormalities: a scientific review

C. Chandan and H. A. Pardhe and K. Nagappan and G. Phani Kumar and B. V. Sushma and M. R. Jeyaprakash (2023) Formulation and stability enhancement using vitamin A encapsulation in ocular abnormalities: a scientific review. International Food Research Journal (Malaysia), 30. pp. 564-576. ISSN 2231 7546

The relationship between vitamin A, retinol activity, and eye health has been briefly elucidated. Based on certain reports, vitamin A and retinol activity can help overcome vitamin A insufficiency i.e., xerophthalmia. The present review assesses vitamin A sources, β-carotene and β-cryptoxanthin in vitamin A metabolism, retinol and xerophthalmia, and new application of vitamin A in mitigating xerophthalmia. Vitamin A and its precursors are sensitive, and could lose their biological activity when exposed to light or oxygen. In this context, encapsulation may act as a protection strategy for enhancing vitamin A's biological functions under adverse conditions. With the belief that vitamin A and retinol activity have a long-term association with xerophthalmia, the present review discusses the relationship between vitamin A consumption and its precursors, as well as the physiological effects of vitamin A on xerophthalmia. In conclusion, further research using free and encapsulated forms of vitamin A to prevent vitamin A deficiency and manage xerophthalmia should be emphasised.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/30%20(03)%202023/02%20-...

Abstract

The relationship between vitamin A, retinol activity, and eye health has been briefly elucidated. Based on certain reports, vitamin A and retinol activity can help overcome vitamin A insufficiency i.e., xerophthalmia. The present review assesses vitamin A sources, β-carotene and β-cryptoxanthin in vitamin A metabolism, retinol and xerophthalmia, and new application of vitamin A in mitigating xerophthalmia. Vitamin A and its precursors are sensitive, and could lose their biological activity when exposed to light or oxygen. In this context, encapsulation may act as a protection strategy for enhancing vitamin A's biological functions under adverse conditions. With the belief that vitamin A and retinol activity have a long-term association with xerophthalmia, the present review discusses the relationship between vitamin A consumption and its precursors, as well as the physiological effects of vitamin A on xerophthalmia. In conclusion, further research using free and encapsulated forms of vitamin A to prevent vitamin A deficiency and manage xerophthalmia should be emphasised.

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Item Type:	Article
AGROVOC Term:	vitamin a > vitamin a Prefer using retinolretinol
AGROVOC Term:	retinol
AGROVOC Term:	xerophthalmia
AGROVOC Term:	stability
AGROVOC Term:	encapsulation
AGROVOC Term:	formulations
AGROVOC Term:	drug delivery systems
AGROVOC Term:	bioavailability
Geographical Term:	India
Depositing User:	Nor Hasnita Abdul Samat
Date Deposited:	28 Jul 2024 14:15
Last Modified:	28 Jul 2024 14:15
URI:	http://webagris.upm.edu.my/id/eprint/921

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