Synergistic activity of plant prebiotics and Lactococcus lactis KA-FF 1-4 to enhance vancomycin-resistant enterococci (VRE) growth inhibition

Pongsuwanporn T., . and Udomsri P., . and Nitisinprasert S., . and Nakphaichit M., . Synergistic activity of plant prebiotics and Lactococcus lactis KA-FF 1-4 to enhance vancomycin-resistant enterococci (VRE) growth inhibition. pp. 934-940. ISSN 22317546

Synbiotics are products containing both probiotics and prebiotics in which the prebiotic compound selectively favours the probiotic to provide synergistic activity for gut health promotion. Due to its potential probiotic effect Lactococcus lactis KA-FF 1-4 showed inhibitory activity against vancomycin-resistant enterococci (VRE). Its synergistic activity with three commercial plant prebiotics namely inulin fibersol-2 and XOS is presented in the present work. In vitro batch fermentation with each prebiotic supplement had no effect on the growth rate of L. lactis KA-FF 1-4. However supplementation with either 2 w/v inulin or fibersol-2 dramatically enhanced anti-VRE activity. Further study was performed on the effect of various concentrations (0.5 1 2 and 5) of inulin or fibersol-2 on anti-VRE activity. In co-culture L. lactis KA-FF 1-4 with 1 inulin supplementation could apparently reduce the VRE concentration from log 4.0 to 2.7 CFU/mL after 12 h while complete inhibition was observed with 2 fibersol-2 supplementation after 6 h. These results clearly showed the synergistic effect on VRE growth inhibition which may serve as a guideline for the development of synbiotic formulations in the future.

Full text available from: Official URL: http://www.ifrj.upm.edu.my/27%20(05)%202020/DONE%2...

Abstract

Synbiotics are products containing both probiotics and prebiotics in which the prebiotic compound selectively favours the probiotic to provide synergistic activity for gut health promotion. Due to its potential probiotic effect Lactococcus lactis KA-FF 1-4 showed inhibitory activity against vancomycin-resistant enterococci (VRE). Its synergistic activity with three commercial plant prebiotics namely inulin fibersol-2 and XOS is presented in the present work. In vitro batch fermentation with each prebiotic supplement had no effect on the growth rate of L. lactis KA-FF 1-4. However supplementation with either 2 w/v inulin or fibersol-2 dramatically enhanced anti-VRE activity. Further study was performed on the effect of various concentrations (0.5 1 2 and 5) of inulin or fibersol-2 on anti-VRE activity. In co-culture L. lactis KA-FF 1-4 with 1 inulin supplementation could apparently reduce the VRE concentration from log 4.0 to 2.7 CFU/mL after 12 h while complete inhibition was observed with 2 fibersol-2 supplementation after 6 h. These results clearly showed the synergistic effect on VRE growth inhibition which may serve as a guideline for the development of synbiotic formulations in the future.

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Item Type:	Article
AGROVOC Term:	Lactococcus lactis
AGROVOC Term:	Probiotics
AGROVOC Term:	Synergistic effect
AGROVOC Term:	Drug resistance
AGROVOC Term:	Fermentation
AGROVOC Term:	Inulin
AGROVOC Term:	In vitro
AGROVOC Term:	Growth inhibition
AGROVOC Term:	Lactic acid bacteria
AGROVOC Term:	Glycopeptides
Depositing User:	Mr. AFANDI ABDUL MALEK
Last Modified:	24 Apr 2025 00:55
URI:	http://webagris.upm.edu.my/id/eprint/9410

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