Nutritional status and other predictors of immune response recovery among HIV-AIDS patients receiving antiretroviral therapy in Dr. Sardjito Hospital Yogyakarta Indonesia: a retrospective cohort study


Citation

Subronto Yanri Wijayanti, . and Asturiningtyas Ika Puspita, . and Kusmayanti Nur Aini, . Nutritional status and other predictors of immune response recovery among HIV-AIDS patients receiving antiretroviral therapy in Dr. Sardjito Hospital Yogyakarta Indonesia: a retrospective cohort study. pp. 441-452. ISSN 1394–035X

Abstract

Introduction: Nutritional status and immune response of Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome (HIV-AIDS) patients are closely connected. There are limited studies assessing the influence of Body Mass Index (BMI) on immune response recovery among HIV patients in Indonesia. This study aimed to identify the BMI and other predictors of immune response recovery among HIV-AIDS patients following two years of Antiretroviral (ARV) therapy. Methods: This research was a retrospective cohort study among HIV-AIDS patients who started ARV therapy from January 2014 to December 2016 at Dr. Sardjito Hospital Yogyakarta. Data were collected from ARV registry and medical reports. Data were analysed using linear regression. Results: A total of 255 patients were included in the study with a median BMI of 20.07 kg/m. Results showed that BMI was not significantly correlated with immune response recovery at the 6th 12th 18th and 24th months of ARV therapy (p0.05). But the increase in cluster of differentiation 4 (CD4) cell count was higher in overweight and pre-obese patients than underweight patients especially in the 18th and 24th months of therapy. Factors related to immune response recovery were the regularity of treatment at the 12th 18th and 24th months of ARV therapy and the use of Tenofovir at 18th-month therapy (p0.05). Conclusion: Immune response recovery was higher in overweight and pre-obese patients. Using Tenofovir type ARV and doing treatment regularly can increase CD4 cell counts. Underweight patients need to enhance their nutritional status to improve their immune response during ARV therapy.


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Abstract

Introduction: Nutritional status and immune response of Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome (HIV-AIDS) patients are closely connected. There are limited studies assessing the influence of Body Mass Index (BMI) on immune response recovery among HIV patients in Indonesia. This study aimed to identify the BMI and other predictors of immune response recovery among HIV-AIDS patients following two years of Antiretroviral (ARV) therapy. Methods: This research was a retrospective cohort study among HIV-AIDS patients who started ARV therapy from January 2014 to December 2016 at Dr. Sardjito Hospital Yogyakarta. Data were collected from ARV registry and medical reports. Data were analysed using linear regression. Results: A total of 255 patients were included in the study with a median BMI of 20.07 kg/m. Results showed that BMI was not significantly correlated with immune response recovery at the 6th 12th 18th and 24th months of ARV therapy (p0.05). But the increase in cluster of differentiation 4 (CD4) cell count was higher in overweight and pre-obese patients than underweight patients especially in the 18th and 24th months of therapy. Factors related to immune response recovery were the regularity of treatment at the 12th 18th and 24th months of ARV therapy and the use of Tenofovir at 18th-month therapy (p0.05). Conclusion: Immune response recovery was higher in overweight and pre-obese patients. Using Tenofovir type ARV and doing treatment regularly can increase CD4 cell counts. Underweight patients need to enhance their nutritional status to improve their immune response during ARV therapy.

Additional Metadata

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Item Type: Article
AGROVOC Term: HIV/AIDS
AGROVOC Term: HIV
AGROVOC Term: AIDS
AGROVOC Term: Human immunodeficiency virus
AGROVOC Term: HIV infections
AGROVOC Term: Disease treatment
AGROVOC Term: Immunotherapy
AGROVOC Term: Medicines
AGROVOC Term: Nutritional status
AGROVOC Term: Immune response
Depositing User: Mr. AFANDI ABDUL MALEK
Last Modified: 24 Apr 2025 00:55
URI: http://webagris.upm.edu.my/id/eprint/9780

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